Women's Cardiovascular Disease Research

Dr. Quesada and her team apply the latest clinical and scientific research findings to provide patients with the most effective and cutting-edge treatment options. As a translational clinical investigator with expertise in women's cardiovascular disease and prevention, Dr. Quesada focuses on cardiac diseases that affect women predominantly, including: 

  • Ischemia with no obstructive coronary artery disease (INOCA)

  • Coronary microvascular dysfunction (CMD)

  • Coronary vasospasm

  • Myocardial infarction with no obstructive coronary artery disease (MINOCA)

  • Spontaneous coronary artery dissection (SCAD)

  • Takotsubo cardiomyopathy (broken heart syndrome)

  • Link of hypertensive disorders of pregnancy and cardiovascular disease

Dr. Quesada is the recipient of a prestigious million-dollar grant from the National Institutes of Health (NIH) and, in addition to directing the Women's Heart Center, will lead a landmark research program on women's cardiac health and disease at The Christ Hospital's Lindner Center. "The focus of my NIH research study is to better understand why women with preeclampsia in pregnancy are at increased risk of cardiovascular disease later in life," she explains. "I will also lead, along with Dr. Timothy Henry, research studies on INOCA and coronary microvascular disease in women. Only through research can we close the gaps in women's heart disease."

Current Studies

We are actively enrolling for research studies in women's heart disease at The Linder Research Center, including trials in cardiac diseases that predominantly affect women and are largely understudied including INOCA and coronary microvascular disease and women specific risk factors for cardiac disease such as hypertensive disorders of pregnancy including. See a list below of current studies, with links to more information.

Hypertensive Disorders of Pregnancy: Pathways to Future Cardiovascular Disease

If you have had a pregnancy in the last 10 years and were diagnosed with preeclampsia during your pregnancy, you may be qualified for a study on the effects of preeclampsia on heart structure and function. We are also seeking women who had healthy pregnancies to serve as the comparison group to help us better understand the differences between normal pregnancies and those complicated by preeclampsia. To see if you qualify and to view other details like compensation and how to sign up, please view the flyer here.

Women's Ischemia Trial to Reduce Events in Non-Obstructive Coronary Artery Disease (WARRIOR)

We are seeking women with ischemia (angina or equivalent symptoms) who have been told they have non-obstructed coronary arteries based on a coronary angiogram or coronary CT angiogram within the past 5 years. Ischemia but no obstructive coronary artery disease (INOCA) is more common in women and the WARRIOR study seeks to determine if intensive medical therapy can reduce major adverse cardiovascular events and increase quality of life in these women. To see if you qualify or to learn more about the study, you can view the flyer here.

The Freedom Trial

For patients with ischemia and non-obstructed coronary arteries (INOCA) and frequent chest pain who are unable to tolerate medications or have chest pain despite medications the Freedom Trial may be a good option for you. The Freedom Trial seeks to use your own cells to improve the function of the microvascular system of the heart (small coronary arteries) and reduce your angina.

For more information for any of our studies please contact the Lindner Research Center at: 513-585-1777

Registries

Registries are research studies where information is collected to better understand diseases. All women cared for at the Christ Hospital Women's Heart Center will be asked to be part of the Women's Heart Center Registry to collect data and better understand cardiovascular diseases more commonly seen in women and poorly studied.

OPTIMIST (Options in Myocardial Ischemia Syndrome Therapy Long-term follow-up database) Registry

This registry aims to better understand patients with refractory angina reluctant to medical therapy.